Azelaic Acid Gel vs Cream: Is There A Difference & Which Is Best?

Azelaic Acid Gel vs Cream: Is There A Difference & Which Is Best?

Dermatologist Insights
Founder of Foundation Skincare, Dr. Nuara earned his MD PhD from Saint Louis University School of Medicine with a focus in Molecular Microbiology and Immunology. He completed his advanced dermatology training at top ranked University of Texas Southwestern Medical Center. His expertise in neutraceuticals and original formulations has helped hundreds of patients with hair loss and skin conditions.

With potent anti-bacterial and anti-inflammatory properties, azelaic acid is one of the most highly touted skincare ingredients for those dealing with skin conditions like mild rosacea, acne, and hyperpigmentation. In the past, products containing this multi-tasking ingredient were only available with a prescription. These days, azelaic acid is much more accessible, but not all products are created equally. 

We’ve asked Dr. Anthony Nuara, MD PhD FAAD, to explain the difference between azelaic acid gels and creams and how to choose the right product for your skin.

Azelaic Acid’s Role in Skincare

A member of the dicarboxylic acids, azelaic acid contains antioxidants that neutralize environmental stressors and free radicals that can cause acne breakouts, blemishes, irritation, and inflammation in your skin. It efficiently unclogs pores by clearing away bacteria and encouraging cell turnover to heal acne and reduce scarring.

Azelaic acid helps to decrease hyperpigmentation by impeding the synthesis of melanin, the skin pigment that contributes to your skin tone. Even more, azelaic acid inhibits the conversion of testosterone to 5-dihydrotestosterone, which can minimize breakouts and hyperpigmentation caused by hormonal imbalances.1

Azelaic Acid Cream

Generally recommended for people with dry or sensitive skin, azelaic acid creams have a thick and creamy consistency, and absorb slowly into the skin. They can have a moisturizing quality, especially if the product contains other soothing ingredients like aloe or jojoba seed oil. 

Foundation Skincare’s Azelaic Acid 14% Cream is a cream-based formulation containing a medical-grade concentration of the active ingredient alongside aloe leaf juice, jojoba seed oil, avocado oil, and coconut fruit extract.

Formulation & Texture

Our goal in creating FS Azelaic Acid 14% Cream was to make an elegant cream base rather than the typical drying gels and gritty mass- produced products. To ensure the softest and gentlest formulation, our product is hand-milled to a smooth consistency.


Azelaic acid is really a catch-all ingredient. It helps with the redness of acne and rosacea as well as the pigmentation left behind. As far as the benefits of using a cream-based product, you can expect less irritation and dryness, even for those with sensitive skin. The product will also not leave a sticky residue or pill. In addition to using azelaic acid for rosacea, acne, and hyperpigmentation disorders, there is also evidence the ingredient has anti-aging qualities; it helps to improve skin elasticity and reduce wrinkles and fine lines.2


  • Apply Azelaic Acid 14% Cream last in your skincare routine, but before sunscreen for a morning application. You can use it alone or mix with a small amount of your favorite moisturizer.
  • Only use a pea-sized amount of Azelaic Acid 14% Cream and gently apply a thin layer to your entire face, avoiding your eyes, lips and mouth.
  • Use once or twice daily depending on your skin type. You can also build up to using the product if you have sensitive skin, applying every other day over 2-3 weeks until your skin acclimates.
  • Protect with a minimum SPF 30 (50 preferred) mineral-based broad-spectrum sunscreen in the morning and as the last product in your skincare routine.

Recommended products to use alongside azelaic acid: FS Hyaluronic Acid Lotion, which works as a magnet for hydration. FS Niacinamide Lotion 10%, which helps to balance sebum (oil) production and further fade hyperpigmentation. FS Night Renewal Cream with 2% Granactive Retinoid to encourage collagen synthesis, reduce signs of premature aging and accelerate cell turnover. Use with Spectrum Antioxidant Supplement to promote skin health from the inside out. 

What Skin Type is it Best Suited For? 

One of the best qualities about azelaic acid is that it is safe and effective for all skin types and colors. It is worth noting that some prescription concentrations of azelaic acid ranging from 15%-20% of the active ingredient can be irritating for those with sensitive skin. On the other hand, most over-the-counter formulations only contain around 10% of the active ingredient, which may not produce the results you’re looking for. FS Azelaic Acid 14% Cream contains just the right amount of the active ingredient to make it effective and gentle enough for sensitive skin.

Azelaic Acid Gel

Azelaic acid gels are often recommended for those with oily skin because of their quick absorption. With a fluid-like consistency, these products are lightweight and typically do not leave behind a residue. 

Formulation & Texture: 

Azelaic acid gels are generally mass-produced and prepared in a gel formulation to boost their solubility. They can feel lighter on the skin due to their fluid-like consistency but are not as hydrating because they dry so quickly. 


Azelaic acid in a gel-based form can deliver the active ingredient more quickly into the skin and it won’t leave behind a sheen on the skin or appear greasy. However, its fast absorption can make skin feel dried out, tight, or irritated. 


After washing skin and patting dry, azelaic acid should be applied to dry skin in a thin layer. It can be gently massaged into the skin. After it is fully absorbed, you can follow up with your other skincare products as directed by your dermatologist. 

Azelaic Acid Cream vs Gel: Key Differences

Still not sure which azelaic product is right for your skin? Review these key differences between creams and gels:

  • Azelaic creams are more suitable for dry or sensitive skin due to their moisturizing effect. 
  • Gels are generally more drying and can be more irritating to sensitive skin.
  • Creams absorb slowly and won’t leave behind a sticky residue. 
  • Azelaic gels absorb quickly, which may deliver ingredients faster and penetrate more deeply, but they can also cause tightness and flakiness due to this fast absorption rate.  

Choosing the Right Formulation

Some dermatologists suggest cream-based azelaic acid products for sensitive or dry skin due to their slow absorption and moisturizing qualities. Gels are generally recommended for those with oily skin. FS Azelaic Acid 14% Cream is formulated to be suitable for all skin types, whether you suffer from excess oil, dryness, or sensitive skin. It powerfully soothes and manages without stinging, redness, or irritation, and will not leave behind a greasy residue.

My Expert Opinion  

If I only had access to one skin care ingredient for my patients, this would be it. So much can be accomplished using this natural molecule, whether you are looking for a more even skin tone, improved skin texture, less acne, less redness, or simply healthier, brighter skin.

Learn more about the benefits of azelaic acid cream and explore more skincare tips in the FS Journal.

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